Role of Monoaminergic Neurotransmission on the Antidepressant Effect of Leaf and Root Extracts of Ra
One of the medicinal plants commonly used to treat hypertension, diabetes, and mental illnesses is Rauwolfia vomitoria. There is a lack of scientific evidence to suggest its medicinal use, especially in mental health care. The purpose of this research was to investigate the antidepressant-like effect of R leaf and root extracts. Vomitory using neurobehavioral indices in the rat model; open field and forced swimming experiments. The effect of the extracts on the system of monoamine neurotransmitters was subsequently investigated. The neurobehavioral response of rats by open field and forced swim test showed that there was a decrease in the exploratory tendencies of aqueous and ethanol root extracts (125, 250, 500 mg/kg) administered to rats compared to control, while the forced swim test decreased the immobility time of rats in all treatment groups except 500 mg/kg. The plasma and brain levels of neurotransmitters (serotonin, dopamine and norepinephrine) in rats treated with different concentrations of root extracts reported substantial increases (p<0.05). The mode of action can therefore be due in part, to a rise in monoamine levels or to the suppression of the reuptake of the neurotransmitters of monoamine. This review found that R. The root extract of vomitoria has antidepressant-like effects in rats. Please see the link :- https://www.journalejmp.com/index.php/EJMP/article/view/30316 [if !supportLineBreakNewLine] [endif]