A New Flame AAS Application for Magnesium Determination in Solid Pharmaceutical Preparations as an A

Objective: A new application of Atomic Absorption Spectroscopy (AAS) was used to determine magnesium as an active ingredient and/or excipient in its solid forms (effervescent and uncoated compressed tablets).

The linear range of magnesium was calculated using the following methodology. The researchers looked at a sample of magnesium effervescent tablets. Using two digestive procedures, the content of magnesium stearate in commercial paracetamol pills was also evaluated indirectly. Finally, the effect of talc on the total magnesium content of a sample of drug-free tablets (only containing excipients) was investigated.

Linear range was seen in magnesium concentrations ranging from 0.08 to 0.40 ug/mL. The percentage of effervescent tablet samples recovered ranged from 98.66 to 103.00 percent, indicating that the product meets criteria. The average concentration of magnesium stearate in paracetamol tablets was 0.2 percent, and there were no differences between the two digesting techniques (t=0.454). In the presence of talc, we found a substantial rise in magnesium concentrations in the drug-free sample.

Conclusion: The AAS method is a simple and quick technique that may be used to estimate magnesium in both in-process and final product analyses.

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