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Accuracy of Combined Measure of Serum Uric Acid and Beta Human Chorionic Gonadotropin (β hCG) Versus

Background: It has been proposed that measuring a variety of biological, biochemical, and biophysical indicators in pregnancy implicated in the pathophysiology of preeclampsia can predict its progression.

At the Federal Medical Centre in Yenagoa, researchers compared the accuracy of a combined assessment of maternal serum uric acid level and quantitative serum beta hCG to serum beta hCG alone as predictive markers of pregnancy outcome in preeclamptic patients.


Methods: A prospective case control study with systematic sampling selection was conducted in a hospital setting. Over the course of the seven-month trial, the two groups of patients, one with pre-eclampsia (study group) and the other without pre-eclampsia (control group), were admitted for care to the prenatal department and labour ward. On admission, their serum uric acid and beta hCG levels were assessed and followed up on. A statistical software for social science was used for data entry and statistical analysis (windows version 22.0. SPSS Inc; Chicago, USA). The significance level was chosen at P 0.05.


The individuals' mean quantitative serum hCG level (26776.6 19590.5) was statistically significantly higher (p 0.001) than the control group's mean quantitative serum hCG level (7973.6 4193.7). For combined measures of serum uric acid and serum hCG, and serum hCG alone, the prognostic accuracy in predicting pregnancy outcomes was: HELLP syndrome (0.33, 0.44), Eclampsia (0.50, 0.39), Acute Renal Failure (0.44, 0.33), IUGR (0.43, 0.39), IUFD (0.38, 0.27), and Birth Asphyxia (0.49, 0.38) respectively.


Conclusion: In preeclamptic women, serum hCG levels remain a valuable prognostic indication for feto-maternal fate. However, a combined measure of serum uric acid and serum hCG level was proven to be more accurate than serum hCG in predicting pregnancy outcome in preeclamptic women.


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