Analysis of the Adverse Drug Reactions and Associated Cost Burden on the Patients in a South Indian.

The aim of this study was to look at adverse drug reactions (ADR) and their economic impact on the health-care system and patients.

Methodologies:

From July 2016 to December 2018, a prospective retrospective study was performed in a South Indian tertiary care teaching hospital.

ADRs were assessed using standard scales for causality, severity, predictability, and preventability, and then reported to the Pharmacovigilance Program of India (PvPI) using a modified Indian Pharmacopoeia Commission (IPC) suspected ADR reporting form. By evaluating ADR management, including clinical investigations, the overall cost burden, both direct and indirect, was estimated.Indirectionthe indirect expense was estimated using the Gross Domestic Product (GDP) of our study area and a per capita analysis. Results: Of the 458 ADRs registered, 81.88 percent were in the adult population, with nearly equal occurrence in both genders, the remainder were probable (41.70 percent), and antibiotics were the most common cause (16.18 percent ). Around 60% of ADRs were treated with at least one prescription, and 27% of ADRs necessitated hospitalisation or a longer stay in the hospital. The hospital and the patients spent a total of 989164.5 Indian Rupees (INR) on the management of ADRs, with 79 percent of the cost being direct and 21 percent being indirect. Conclusion: In this hospital, 26.88% of patients had ADRs that were correlated with high direct costs due to hospitalization/extended hospitalizations, resulting in an additional economic strain on the healthcare system and a need for ADR management.

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