Antifeedant Activity of Pyrazolin-5-One Derivatives | Journal of Pharmaceutical Research

The biological activity of a sequence of substituted 4-1-aza-2-[(aryl) amino)]-3-methyl-2-pyrazolin-5-ones has been investigated. The title compounds (4a-l) were made by diazotizing substituted anilines (1a-l) to produce substituted phenyl hydrazine derivatives (2a-l), which were then used to make substituted 4-1-aza-2-[(aryl) amino)]-3-methyl-2-pyrazolin-5-ones (4a-l) through the Michael addition reaction, which is the nucleophilic addition of an enolate anion to the carbon-carbon double bond. The researchers produced 12 different pyrazolinone derivatives (4a to 4l). Elemental analysis, FTIR, 1HNMR, and Mass spectral data were used to assign structural assignments to these compounds, and TLC was used to determine purity. The newly isolated heterocyclic compounds were tested for antifeedant activity against the agricultural pest Achoea janata. The antifeedant activity of compound 4d was found to be very high, while the rest of the compounds had moderate to strong antifeedant activity.

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