Antifeedant Activity of Pyrazolin-5-One Derivatives | Journal of Pharmaceutical Research Internation

The biological activity of a sequence of substituted 4-1-aza-2-[(aryl) amino)]-3-methyl-2-pyrazolin-5-ones has been investigated. The title compounds (4a-l) were made by diazotizing substituted anilines (1a-l) to produce substituted phenyl hydrazine derivatives (2a-l), which were then used to make substituted 4-1-aza-2-[(aryl) amino)]-3-methyl-2-pyrazolin-5-ones (4a-l) through the Michael addition reaction, which is the nucleophilic addition of an enolate anion to the carbon-carbon double bond The researchers produced 12 different pyrazolinone derivatives (4a to 4l). Elemental analysis was used to assign structural assignments to these compounds.

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