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Antiphospholipid Antibodies in Young Adults with Myocardial Infarction | Asian Journal of Cardiology

The aim of this study was to determine the prevalence of antiphospholipid antibodies in young (45-year-old) MI (myocardial infarction) patients and to look for a connection between antiphospholipid antibodies and traditional MI risk factors.The study was designed as a case-control study.

Between November 2018 and March 2020, at the Departments of Pathology and Medicine, University College of Medical Sciences, and Guru Teg Bahadur Hospital in Delhi.The research included forty young MI patients (aged 45) and 30 age-matched controls.

Complete blood counts (Automated haematology analyzer), Prothrombin time, Activate partial thromboplastin time (Automated coagulometer), Lupus anticoagulant test (ISTH criteria), Anticardiolipin antibodies IgG and IgM, and Anti-2 glycoprotein I IgG (ELISA) were all performed on all patients and controls. The mean, standard deviation,and median values of the quantitative parameters were calculated using SPSS (20) software, and the frequencies of all qualitative parameters were determined using SPSS (20). Antiphospholipid antibody positivity was measured in percentages.The Chisquare test and Fisher's exact test were used to see whether antiphospholipid antibodies were linked to other risk factors. For each risk factor, the Odds Ratio was determined.A statistically significant P value of less than 0.05 was used.Smoking, obesity, diabetes mellitus, hypertension, and dyslipidemia were all found to be risk factors in all of the patients.

Antiphospholipid antibodies were found in 6 (15%) of the patients and 1 (3.3%) of the control subjects.

Antiphospholipid antibodies positive patients have a variety of traditional risk factors.

Antiphospholipid antibodies were found to have no major relationship with traditional MI risk factors.

Conclusion: Antiphospholipid antibodies were found in 15% of young MI patients, all of whom had typical risk factors. As a result, in these patients, a work-up for these antibodies might be used.



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