Assessment of Toxicity of Selenium Nanoparticle Varnish Using HepG2 Cell Lines: In vitro Study | Jou

In mammalian biology, selenium, an important trace element, plays a significant role. Due to its bioavailability, low toxicity, protein interaction and biocompatibility, Selenium nanoparticles (SeNPs) have gained considerable importance. The purpose of this study is to determine the cytotoxicity of SeNPs by testing the HepG2 cell line. MTT assays were used to study the cytotoxicity of nanoparticles in the HepG2 cell line. Using Graph Pad Prim5 software, cytotoxicity was calculated. With 77 percent, 63 percent and 33.7 percent of cell viability at 2μg/ml, 4μg/ml and 30μg/ml concentration, the SeNPs demonstrated cytotoxic activity against the HepG2 cell line. Cytotoxic activity against the HepG2 cell line has been shown by biogenic SeNPs and therefore warrants more research on its biosafety and potential oral antimicrobial agent.

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