Association between Polycystic Ovary Syndrome and Breast Cancer: A Review | Asian Research Journal o

The goal of this study is to learn more about polycystic ovarian syndrome (PCOS), a prevalent endocrine condition that affects women of reproductive age. Some of the key risk factors for breast cancer are the hormonal profile and comorbidities prevalent in women with PCOS, such as obesity and diabetes. The purpose of this review is to look into the possibility of a link between PCOS and breast cancer. The epidemiological evidence, the relationship of PCOS-related symptoms and PCOS treatments with the prevalence of breast cancer are the subject of this review.

Methodology: A systematic literature search was conducted using Ovid MEDLINE, Google Scholar, and PubMed to locate epidemiologic studies that reported on the link between PCOS and breast cancer published in the last ten years (from 2010 to June 25, 2020). Polycystic ovarian syndrome, breast cancer, and breast neoplasms were utilised as keywords.

The majority of epidemiological research found no evidence of a link between PCOS and breast cancer. Elevated androgen and oestrogen levels, on the other hand, have been linked to an increased risk of oestrogen receptor positive breast cancer. In addition, women with obesity, hyperinsulinemia, and a low level of sex hormone binding globulin had a higher risk of breast cancer, according to this study. Unlike metformin and clomiphene citrate, combined hormonal contraception is associated to a greater risk of breast cancer when used as a first-line treatment for PCOS.

Conclusion: Because the clinical data from this analysis are inconsistent, a strong conclusion about the link between PCOS and breast cancer cannot be drawn, underlining the need for further prospective research in the future.

Please see the link :- https://www.journalarjgo.com/index.php/ARJGO/article/view/30143