Association between Subclinical Hypothyroidism and Albuminuria in Patients with Type 2 Diabetes ..

The connection between subclinical hypothyroidism and type 2 diabetes has been proven in studies. However, common type 2 diabetes complications such as diabetic nephropathy and albuminuria with subclinical hypothyroidism are still unknown.The aim of this study was to see if there was a connection between subclinical hypothyroidism and albuminuria in people with type 2 diabetes.Methods: This was a crosssectional analysis of 140 people diagnosed with type 2 diabetes mellitus (DM) who wereadmitted to Kosar Hospital's internal clinics in Semnan, Iran, between 2017 and 2018. Patients were divided into two groups based on demographic information, laboratory information, and indicators such as albuminuria and urinary albumin-to-creatinine ratio, and were compared based on having two TSH levels above average (>4.2 mIU/L) 3 months apart. Patients were also divided into two groups based on demographic information, laboratory information, and indicators such as albuminuria and urinary albumin-to-creatinine ratio (UACR). Findings: In patients with subclinical hypothyroidism, the mean and standard deviation of UACR were substantially higher than in euthyroid patients (46.09 27 9.27 vs. 3.94 0.24and P = 0.015, respectively). There was a statistically important and direct association between UACR values and primary TSH level (r = 0.555, P 0.001) and UACR values and secondary TSH level (r = 0.563, P 0.001) in patients with subclinical hypothyroidism.Conclusion: In type 2 diabetes patients with subclinical hypothyroidism, the incidence of albuminuria was substantially higher than in euthyroid patients, and UACR values and, as a result, albuminuria increased with increasing initial and recurrent TSH levels.

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