Association between Subclinical Hypothyroidism and Albuminuria in Patients with Type 2 Diabetes Mell

The link between subclinical hypothyroidism and type 2 diabetes has been proven in studies. However, typical type 2 diabetes consequences such as diabetic nephropathy and albuminuria with subclinical hypothyroidism are yet unknown. The goal of this study was to see if there was a link between subclinical hypothyroidism and albuminuria in people with type 2 diabetes.

Methods: This was a cross-sectional research of 140 people diagnosed with type 2 diabetes mellitus (DM) who were hospitalised to Kosar Hospital's internal clinics in Semnan, Iran, between 2017 and 2018. Patients were divided into two groups based on demographic information, laboratory information, and indicators such as albuminuria and urinary albumin-to-creatinine ratio, and were compared based on having two TSH levels above normal (>4.2 mIU/L) 3 months apart. Patients were also divided into two groups based on demographic information, laboratory information, and indicators such as albuminuria and urinary albumin-to-creatinine ratio (UACR).

Findings: In patients with subclinical hypothyroidism, the mean and standard deviation of UACR were substantially greater than in euthyroid patients (46.09 27 9.27 vs. 3.94 0.24 and P = 0.015, respectively). There was a statistically significant and direct link between UACR values and primary TSH level (r = 0.555, P 0.001) and UACR values and second TSH level (r = 0.563, P 0.001) in patients with subclinical hypothyroidism.

Conclusion: In type 2 diabetes patients with subclinical hypothyroidism, the rate of albuminuria was considerably greater than in euthyroid individuals, and UACR values and, as a result, albuminuria increased with increasing initial and recurrent TSH levels.

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