Blood Cellular Changes Associated with Bacteremia and Malaria Co-morbidity among Children in Western

Background: In children with malaria and bacteremia, changes in blood cellular components occur.

In resourceconstrained healthcare settings, complete blood counts from children whose haemoglobin genotypes and bacteremia tests are unknown have a significant impact on clinical management and understanding of haematology findings.

The aim of this study was to look into the cellular components of children who had bacteremia and malaria co-morbidity. In western Kenya, we also looked at haemoglobin genotypes and bacteria isolates from children with haemoglobin AA, SS, and AS.

Methods: A total of 384 children were enlisted in the study, and full blood counts were performed using an automated cell counter. Malaria infections were determined by microscopy, while bacteremia was determined by blood culture. Electrophoresis was used to examine the genotypes of haemoglobin.

Granulocyte counts were higher in children with haemoglobin AA and AS.

The majority of the bacteria isolates came from kids who had malaria and haemoglobin A.Nontyphi salmonella, Escherichia coli, Enterobacter cloacae, Staphylococcus aureus, Listeria monocytogenes, Streptococcus pyogenes, and Viridans were among the bacteria isolated from blood culture.The most common bacteria isolates associated with bacteremia in children with haemoglobin AS and malaria positive were Salmonella species and Staphylococcus aureus.

Conclusion: Malaria and bacterial coinfection are more common in children with Hb AS, resulting in lymphocytopenia, erythrocytopenia, and thrombocytopenia. Salmonella species and Staphylococcus aureus arethe bacteria that cause the majority of malaria co-infections in this area. In pre school infants, malaria and bacterial coinfection causes distinct cellular changes that should be studied further.

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