Clinical and Electrophysiological Aspects of Charcot – Marie Tooth Disease- A Case Report of Two ..

In the absence of genetic studies, investigate the value of electrophysiological tests in diagnosing inherited motor sensory neuropathy.The research was conducted in a cross-sectional manner.Department of Physiology, Pt. B.D. Sharma Post Graduate Institute ofMedical Sciences, Rohtak, Haryana, India, and period of study: Methodology: The patients were referred to the Department of Physiology for nerve conduction, F-wave, EMG, VEP, and BERA research from the Department of Medicine.On electrophysiological review, the median nerve, ulnar, tibial, and peroneal nerves all had symmetrically decreased motor conduction velocity (less than 38 m/sec), with decreased amplitude and increased distal motor latencies, except in the first patient, where the left peroneal nerve conduction velocity was not recordable with decreased amplitude and increased distal motor latencies. In both patients, sensory conduction velocities for bilateral median nerves were reduced with increased latency and decreased amplitude. In the first patient with increased latencies, the sensory conduction velocity and amplitudes of bilateral sural nerves were reduced.Nonetheless,In the other patient, the sensory conduction velocity of the bilateral sural nerves could not be measured. In the first patient, EMG demonstrates a decline in motor unit potential recruitment and amplitude in the bilateral tibial, peroneous, abductor digiti minimi, and 1st dorsal interosseus muscles. EMG revealed denervation in the proximal upper and lower limb muscles. EMG was not recommended for the second patient. One patient's VEP had an increased latency of the P100 wave, while the other's VEP was standard. Both patients' brainstem auditory evoked potentials were natural.

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