Cryptosporidiosis: A Potential Anti-diarrheal Natural Product Drug Discovery Journey in Ghana,...

The overwhelming resistance to existing medications, as well as the depletion of drug development interventions and synthetic libraries, has forced researchers to turn to natural product-derived novel drug candidates.Cryptosporidium, the organism that causes Cryptosporidiosis, is no different. The diarrheacausing parasite is the leading cause of death in children under the age of five in developing countries such as Ghana, and is second only to rotavirus as the causeof diarrhoea in newborn calvesand babies.Nitazoxanide is currently the only FDAapproved drug for the treatment of Cryptosporidiosis. As a result, novel alternative candidates must be developed in order to help in the reduction of infant mortality and malnutrition in developing countries. Despite major limitations in the production of anti-cryptosporidial drugs in vitro and in vivo, important progress is being made, and this article discusses the need for natural product research. Some of the studies cited in this paper suggest that plant extracts may be effective against cryptosporidiosis.We are confident of making major strides in the field of natural product Cryptosporidium drug development in Africa with the abundance of medicinal plant products and Cryptosporidium in vitro culture expertise available in our laboratories at Noguchi Memorial Institute for Medical Research.

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