Deciphering the Genetic Alterations in SPARC Gene Family and Its Association with HNSCC | Journal of

The aim of this study is to find a genetic change in the SPARC gene family that is linked to head and neck squamous cell carcinoma (HNSCC). Squamous cell carcinoma of the oral cavity, nose, throat, larynx, and pharynx is a group of cancerous lesions that arise from the mucous membrane of the oral cavity, nose, throat, larynx, and pharynx. The SPARC gene codes for osteonectin, a cysteine-rich acid matrix metalloprotein with higher expression in metastatic OSCC (Oral squamous cell carcinoma). This expression pattern was also linked to the worst invasion and differentiation patterns in OSCC tumours. In light of the foregoing, the current research was conducted to determine gene changes and their effects. Using computational tools, the putative association of gene changes with HNSCC was also investigated. In this study, the Cancer Gene Atlas (TCGA, Firehose Legacy) dataset hosted by the cBioportal server was used. Using the IMutant and PROVEAN techniques, the non-synonymous variants were tested for protein stability and pathogenicity. Gene amplification was found in the FSTL1 gene, which also had the highest frequency of gene modifications (5%) among the eight genes studied. Furthermore, different grades of HNSCC had markedly different levels of FSTL1 gene expression. Finally, the research sheds light on the possibility of the SPARC family's FSTL1 gene being linked to HNSCC.

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