Effect of Aqueous Extract of Costus afer Stems on the Liver and Cardiac Enzymes Activities of High..

The purpose of this study was to see how an aqueous extract of Costus afer stems affected the activity of liver and cardiac enzymes in diet-induced hyperlipidemic rats.

Methodology: Wistar albino male rats weighing 100-135 grammes were divided into seven groups of 12 rats each. For two weeks, Group I had a routine diet as normal control rats, whereas the other groups received a high fat diet (10g eggyolk/day). The plant extract was given orally to the treatment groups for four weeks at varied dosages of 400, 800, and 1600 mg/kg b.w alone and in combination with the reference medication, Atorvastatin® (0.26 mg). At regular intervals, the activity of liver and cardiac enzymes were monitored (2 weeks).

After two weeks of feeding with an egg yolk supplemented diet, plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activity were significantly different (p0.05) in all test groups when compared to normal and hyperlipidemic control rats. When compared to normal and hyperlipidemic control rats, plasma AST, ALT, and ALP activity of rats in groups IV, V, and VII decreased significantly (p0.05) after 2 and 4 weeks of treatment (groups I and II). After two weeks of feeding with a high fat diet, all of the test groups had a significant (p0.05) difference in creatine phosphokinase (CPK) activity as compared to the normal control rats. When compared to normal and hyperlipidemic control rats, animals in groups III, IV, and VI (HTR on atorvastatin, 0.26mg, HTR on aqueous extract, 400 mg/kg, and 1600 mg) had significantly lower cholesterol levels after 2 and 4 weeks of treatment.

conclusions: Costus afer stem extract may prevent hepatocyte injury and may also be cardioprotective against myocardial injury, according to this study.

Please see the link :- https://www.journalajrb.com/index.php/AJRB/article/view/30153