Effect of Ascorbic Acid on Glyphosate-Induced Residues in Muscles of Juvenile Catfish (Clarias ..

Aims: This research looked at the acute toxicity of glyphosate and its long-term effects on the muscles of juvenile Clarias gariepinus fish, as well as the use of L-ascorbic acid (vitamin C) to treat induced glyphosate residues in the fish's muscles to avoid glyphosate bioaccumulation and eventual toxicity when ingested by humans. Latin square as a study design. Between December 2018 and April 2019, I studied at the Department of Fisheries and Aquaculture Management at Nnamdi Azikiwe University in Awka, Nigeria.Methodology: To assess the LC50 of both glyphosate (Delsate®) and Vitamin C (Kepro®), 48-hour acute toxicity tests were performed on eight juveniles of C. gariepinus with a mean weight of 41.501.35g and a length of 20.750.43cm. The fish were then subjected to sub-lethal concentrations of glyphosate for 91 days (control), 5.0, 10.0, and 15mgL-1, and then treated separately with 50 and 100 mgL-1 vitamin C for 7 days. A second group of fish was given glyphosate and vitamin C at the same time for 91 days. Gas chromatography was used to assess glyphosate residuesin the muscles of the fish.Delsate® and Kepro® had LC50s of 75 mgL1 and 175 mgL1, respectively. As compared to the monitor, mean values of glyphosate retained in muscles of fish exposed to glyphosate for 91 days increased significantly (P.05). Vitamin C treatment seven days after exposure resulted in a substantial decrease (P.05) in glyphosateresidues in fish muscles, with 100mgL-1 vitamin C being more effective than 50 mgL 1 vitamin C. On the muscles of C. gariepinus, the second set-up had no important therapeutic effects. Conclusion: The LC50 of glyphosate and Vitamin C are calculated in this study. Treatment of exposed fish in a water bath containing Vitamin C may make glyphosate residuesin their muscles healthy for human consumption. Histopathological alterations in tissues of glyphosate-exposed C. gariepinus juvenile fishes are the focus of our current study.

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