Effect of the Chromatographic Fractions of Abrus precatorius Leaf on the Histology of Uterus and...

The aim of this study was to see how different chromatographic fractions of Abrus precatorius leaf extracts affected the histology of the ovary and the uterus. The Abrus precatorius vine, which belongs to the Fabaceae (Leguminosae) family, contains twinning forests. The seeds are both red and black. A small, stout brownish pod is also found in Abrus precatorius [1]. The plant can be found growing in bushes, farms, and hedges. Abrus precatorius is a tuberculosis and painful swelling remedy [2]. They can be used as laxatives, expectorants, and aphrodisiacs, according to Ross [3], and are also used to treat urticaria, eczema, stomatitis, and other skin conditions. Conjunctivitis, alopecia areata, migraines, lymphomas/leukemia, and dysmenorrhea are some of the conditions that can affect women. Experiments have shown that the seed has the potential to reduce male and female fertility [4]. According to previous research, the plant Abrus precatorius can destroy cells or cause cell death at the same time, resulting in tumour death [5]. Previous research has shown that extracting the leaves of A. precatorius with methanol has a bronchodilator effect, and it has been used historically in the treatment of asthma [6]. Root extracts have potent antibacterial properties, especially against Staphylococcus aureus (Prabha et al. 2015). In a study conducted in Tanzania, it was determined that boiling the leaves of A. precatorius with water and taking three table spoonfuls twice daily for the treatment of epilepsy is effective [7]. Female wistar rats were given 30 mg/kg, 60 mg/kg, 90 mg/kg, 120 mg/kg, and 150 mg/kg of chromatographic fractions of A. precatorius, F1, F2, F3, and F4 (30 mg/kg, 60 mg/kg, 90 mg/kg, 120 mg/kg, and 150 mg/kg, respectively) for thirty days. A total of 110 Wistar rats were divided into twenty two (22) classes, each with five rats. Before and during the experiment, all of the rats were weighed. Phosphate Buffer Solution (PBS) was given to Group 1 (Control); 30 mg/kg, 60 mg/kg, 90 mg/kg, 120 mg/kg, and 150 mg/kg of F1 were given to Groups 3-7. F2 was given to groups 8 12 at doses of 30 mg/kg, 60 mg/kg, 90 mg/kg, 120 mg/kg, and 150 mg/kg. Thirty milligrammes per kilogramme were given to Groups 13-17. F3 was given at doses of 60 mg/kg, 90 mg/kg, 120 mg/kg, and 150 mg/kg to Groups 18-22, while F4 was given at doses of 30 mg/kg, 60 mg/kg, 90 mg/kg, 120 mg/kg, and 150 mg/kg to Groups 18 22. Orally, the fractions/drugs were given. The rats were given 30 mg/kg, 60 mg/kg, 90 mg/kg, 120 mg/kg, and 150 mg/kg of chromatographic fractions of A. precatorius, F1, F2, F3, and F4 (30 mg/kg, 60 mg/kg, 90 mg/kg, 120 mg/kg, and 150 mg/kg, respectively) for 30 days. The animals were slaughtered, dissected, and the uterus and ovaries were taken for histology analysis. The study found histological evidence that the chromatographic fractions of Abrus precatorius leaf had no adverse effects on the Wistar Albino rats' ovary and uterus.

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