Effects of Therapeutic Hypothermia in Critically Ill Patients, Post Cardiopulmonary Arrest | Asian J

Introduction: Cardiac arrest (CA), which occurs outside hospital conditions, is one of the leading causes of death in developed countries and remains responsible for high mortality and morbidity even after successful resuscitation. Hypothermia Therapy (TH) is one of the available therapeutic options aimed at minimizing one of the mechanisms responsible for Post Cardio Respiration Syndrome (PCRS), brain injury arrest after a cardiopulmonary arrest.

Objective: The aim of this study is to clarify the significance of TH after cardiac arrest, in critically ill patients.

Material and Methods: A bibliographic review of the literature, mobilizing the descriptors "Therapeutic hypothermia", "Post cardiopulmonary arrest" and "Critically ill patients". Ten conceivable databases were selected, between 2014-2020, and seven studies were included for analysis.

Results and Discussion: It was found that there are some controversial results. Studies comparing the effects of TH with normothermia have shown similar results regarding neurological recovery, although TH may reduce oxidative damage in some studies. Three of the studies show some beneficial effects, but one shows that these effects will only be beneficial in younger years, in the shortest possible time to ROSC and at the rhythm of CA in ventricular fibrillation. One of the studies showed no beneficial effects on the use of TH.

Conclusion: It can be concluded that although part of the clinical practice has existed for more than a decade and recommendations for use in all patients after ROSC exist, there is considerable controversy and questions about various aspects of implementation. There are still some questions to answer. However, some studies also show good effects of TH (32º-34º) and normothermia (36º).

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