Efficacy of Levosalbutamol/Ipratropium Combination in Early Bronchodilator Reversibility | Journal..

The bronchodilator test is a valuable tool for diagnosing patients with obstructive pulmonary disease by assessing improvements in lung ability with spirometry after inhaling a short-acting bronchodilator medication. Although it was previously available in liquid form, levosalbutamol inhaler is a relatively new short-acting bronchodilator. This research aimed to compare the effects of salbutamol and a new levosalbutamol/ipratropium combination on early reversibility and FEV1 changes observed in bronchodilator tests in order to determine the efficacy of levosalbutamol in acute bronchodilator reversibility.

The outcomes of the bronchodilator examinations of forty-two patients who met the inclusion criteria were evaluated retrospectively. Spirometry study was performed on twenty-four patients who received salbutamol (Group I) and eighteen patients who received a combination of levosalbutamol and ipratropium (Group II) (Group II). The absolute and percentage changes in FEV1 were used to determine reversibility levels.

Results: In the salbutamol (Group I) group, absolute and percentage changes in mean FEV1 were 159118 mL, 12.2 percent 11.4%, and 233191 mL, 18.8 percent 15.6 percent in the levosalbutamol / ipratropium (Group II) combination (p=0.025 and 0.048, respectively). Although there was no substantial difference in reversibility scores, Group II had significantly better FEV1 values than Group I.

Please see the link :- https://www.journaljpri.com/index.php/JPRI/article/view/30874