Formulation, Characterization and in-vitro Evaluation of Famciclovir Loaded Solid Lipid ... . . .

The double emulsion-solvent evaporation technique was used to successfully prepare famciclovir-loaded Solid Lipid Nanoparticles (SLNs) using triglycerides as solid lipids. The nanoparticle characteristics were influenced by formulation parameters such as the amount and type of lipid used, as well as the degree of surfactants used. These formulation variables were found to influence nanoparticle characteristics such as average particle size and distribution, drug quality, entrapment performance, and release pattern. Low particle size, in the range of 140-170 nm for Glyceryl monostearate (GMS) and glyceryl distearate (GDS) SLNs and 250-340 nm for glyceryl behenate (GB) SLNs, and entrapment efficiencies of 35-48 percent, were the desired characteristics of the optimised formulations. The Baker-Lonsdale model for spherical particles was used to describe the release profile in vitro for up to 8 hours. Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) morphological analysis revealed homogeneous solid, spherical, and non-porous particles. After lyophilization, the formulations showed strong redispersibility, and the existence of residual solvents within the specified limits indicated that the preparation technique was suitable. Also after 6 months of refrigerated storage, freeze-dried formulations were found to be stable in terms of particle size and drug loading.

Please see the link :- https://www.journaljpri.com/index.php/JPRI/article/view/30879