Hepatoprotective and Reno-protective Effects of Artichoke Leaf Extract and Rosemary Extract.......

In both humans and laboratory animals, paracetamol overdose is a common cause of hepatotoxicity and nephrotoxicity. Plant products are becoming a priority in the quest for a highly efficient and stable medication to avoid paracetamol-induced toxicity. The aim of this study was to see if artichoke (Cynara scolymus L.) Leaf extract and rosemary (Rosmarinus officinalis L.) extract could protect Albino rats from paracetamol-induced toxicity. The rats were divided into five groups: negative control, paracetamol (1000 mg/kg dose) PCT, artichoke leaf extract “ALE” (1.5 g/kg, orally + paracetamol for 30 days), rosemary extract “RE” (125 mg/kg + paracetamol for 30 days), and PCT+ ALE+ RE for 30 days. The activities of serum aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, and lactate dehydrogenase all increased significantly after taking paracetamol. Urea, creatinine, and Cystatin-C levels were all boosted by paracetamol. Furthermore, Serum total protein and albumin levels also dropped significantly. Paracetamol increased lipid peroxidation while lowering reduced glutathione (GSH) levels and glutathione-S-transferase (GST), glutathione (GPX) peroxidase, and glutathione (GPX) peroxidase activities. In the liver and kidney, superoxide dismutase (SOD) is made. The histological examination of the liver and kidney confirms these findings. Conclusion: Treatment with artichoke leaf extract (ALE) and rosemary extract (RE) can protect the liver and kidney from paracetamol-induced biochemical and histological changes as well as oxidative stress.

Please see the link - https://www.journaljpri.com/index.php/JPRI/article/view/30935