Paediatric Osteomyelitis in a Tertiary Hospital in South-South Nigeria; Clinical Experience at ...

The aim of this study was to compare the efficacy and protection of the HHHFNC as a post-extubation respiratory support device in preterm infants who needed endotracheal intubation and a traditional mechanical ventilator after birth at two different flow rates (3 L/min and 6 L/min).

A randomised controlled trial was used in this study.

The study took place in the Neonatal Intensive Care Unit of Tanta University Hospitals' Pediatrics department over a one-year cycle, from December 2018 to December 2019.

Methodology: To avoid postextubation failure, 30 preterm babies with a gestational age of 30 to 36 weeks and a birth weight of less than 1300 g were randomised to receive HHHFNC at either a flow rate of 3 or 6 Lmin. The occurrence of HHHFNC treatment failure at flow rates of 3 and 6 L/min, requiring CPAP or NIMV, or requiring reintubation after successful extubation within 72 hours. The rate of deaths within 72 hours of extubation, the total duration of all forms of oxygen assistance, the total duration of hospitalisation, and the occurrence of neonatal morbidities such as nasal trauma, BPD, symptomatic PDA, IVH grade II, pneumothorax, pulmonary haemorrhage, ROP, apnea, sepsis, and NEC stage II were all secondary outcomes.

The need for a higher flow rate of HHHFNC (n =17, 56.6 percent ), the need for n CPAP or NIMV after failure of a higher flow rate of HHHFNC (n =16, 53.3 percent ), the need for intubation and MV (n =7, 23.3 percent ), the incidence of nasal trauma (n =9, 30 percent ), BPD (n =9, 30 percent ), IVH II (n =7 (56.6 percent ).

Conclusion: In preterm babies, HHHFNC is noninferior to other types of noninvasive respiratory support for preventing extubation failure. At either flow rates of 3 or 6 L/min, HHHFNC had better outcomes in preterm infants with higher gestational age and birth weight.

Please see the link :- https://www.journaljammr.com/index.php/JAMMR/article/view/30695