Serum Copper and Serum Zinc in Preeclampsia: Cause or Effect? | International Journal of ...

Preeclampsia is a multisystem condition that affects both the mother and the baby.The pathophysiology of this multisystem condition is poorly known, despite its prevalence and severity.Concerned about the rising number of preeclamptic cases and a lack of data on trace element levels in preeclampsia, a case-control analysis was conducted to assess trace elements such as serum total copper and serum total zinclevels in preeclampsia.

The aim of this study was to estimate the changes in serum copper and zinc in preeclampsia and compare them to normal pregnant women.The thesis was conducted in the Department of Biochemistry at MIMER Medical College in Talegaon Dabhade, Pune, as a case control study. Methods: A total of 120 people took part in this report.These were split into two categories.Group I consisted of normal pregnant women (n=60) and Group II consisted of preeclamptic women (n=60).At IIT Mumbai, serum copper and zinc levels were calculated using the inductively coupled plasma atomic emission spectrometry (ICP- AES) technique.The mean values of total serum copper and total serum zinc in the control group were 196.20 25.9 (g/dl) and 77.15 14.5 (g/dl), respectively.Copper and zinc levels were 213.13 38.6 and 76.23 13.13 (g/dl) in the preeclamptic population, respectively. When compared to the control group, copper levels were significantly higher in the preeclamptic group, while zinc levels were non-significantly lower.Conclusion: Serum copper levels in preeclamptic patients were found to be substantiallyhigher in this study. High copper levels may be a contributing factor in the etiopathogenesis of preeclampsia.Estimation of trace elements such as copper and zinc may aid clinicians in making an early diagnosis of preeclampsia and minimising or delaying complications, thus preventing harm to both the mother and the foetus.

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