Specifics of Treatment of Hyperuricemia with Febuxostat and Its Effects on Concentrations of Total,

Hyperuricemia is a possible marker for cardiovascular disease, and its link to hypertension, arteriosclerosis, and the outcomes of some cardiovascular events is intriguing. The study enlisted the participation of 50 men and women who were either taking allopurinol or febuxostat. Allopurinol and febuxostat had different effects on uric acid levels and some lipid fractions (total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol) in 25 participants on allopurinol and 25 subjects on febuxostat, respectively.who were chosen by defined criteria, with each patient serving as his or her control. The total observation period was six months and the cut was made after the first three months and at the end of the research. Evaluating the effectiveness of allopurinol in subjects with hyperuricemia, it was established that concentrations of uric acid decreased by 126.28±20.36 µmol/L, at the end of the research, compared to the initial concentration. In subjects who used febuxostat, at the end of the research, concentrations of uric acid decreased by 252.80±94.17 µmol/L, compared to the initial concentration. Evaluating the effectiveness of febuxostat on concentrations of lipid fractions, a statistically significant increase of 0.17±0.02 mmol/L in concentrations of HDL and a statistically significant decrease of 0.37±0.14 mmol/L in concentrations of LDL were noted. Subjects with gout treated with allopurinol had significantly lower average concentrations of cholesterol compared to subjects with gout and metabolic syndrome (p=0.001). Subjects with gout and metabolic syndrome had significantly higher concentrations of LDL at the beginning and the end of the research, regardless of therapy (p=0.045;p=0.049, respectively). Both medicines were successful in the treatment of hyperuricemia and had some influence on lipid fraction concentrations.

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