The Association of Vitamin D with Brain Cognitive Functions: A Literature Review | Journal of Pharma

Vitamin D is a well-known steroid hormone that regulates calcium and phosphorus levels in the bones, as well as general mineralization. Vitamin D deficiency has been associated to an increased risk of Alzheimer's disease and dementia in a number of animal and human studies. The goal of this study is to synthesise what is currently known about the effects of vitamin D insufficiency and supplementation on cognitive function. These impacts' putative underpinning mechanisms were also examined. We reviewed the literature starting from 1986 to 2019 by searching PubMed, Cochrane, Semantic Scholar, Medline, Scopus, and Cochrane Library databases for all observational studies, randomized clinical trials, meta-analyses, and systematic reviews using the keywords“vitamin D and Alzheimer disease”, “neuroprotective effect of vitamin D”, “vitamin D deficiency and Alzheimer ”, “role of vitamin D in neurodegenerative diseases ”, ” vitamin D and amyloidogenesis”, “acetylcholine and vitamin D”, and “memory and vitamin D ”.We also referred to animal and in vitro studies that dealt with the possible mechanisms of actions of the neuroprotective effect of vitamin D. Our findings showed that Vitamin D supplementation improves cognitive performance via reducing amyloidogenesis, Neurotransmission restoration, calcium balance, neurotrophic factor modulation, anti-inflammatory activity, apoptotic regulation, antioxidant, and vascular processes are all important. This review may offer new possibilities in our understanding of disease and neurodegeneration's molecular pathways, allowing for the creation of new therapy and preventative strategies.

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