Antioxidant Properties and Effect of Ethanolic Extract of Pulcria crispa on Biochemical and Hematolo

Pulcria crispa (P. crispa) is a herbal plant that has traditionally been used to treat a variety of diseases.

P. crispa's phytochemical contents, antioxidant activities, and effects on biochemical and haematological markers, as well as safety, were evaluated in albino rats in this study. Standard techniques were used to undertake phytochemical analysis of an ethanolic extract of P. crispa. The antioxidant activity of the extract was investigated in vitro using the 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) and reducing power assays. Acute effects on physical and behavioural changes, as well as mortality, were tracked for up to 72 hours after different doses of C. crispa were given. After 30 days of treatment of different doses of P. crispa extract to rats, the effects on body to organ ratio, biochemical, and haematological parameters were assessed. The most abundant compounds discovered in P. crispa extract were alkaloids, flavonoids, phenols, and tannins, which had considerable antioxidant activity as evaluated by reducing power and DPPH assays. Following acute treatment of rats with the extract, no physical, behavioural, or mortality alterations were observed. Similarly, after continuous treatment, there was no discernible change in the body-to-organ weight ratio. In P.crispa-treated rats, haematological parameters such as RBCs, Hb, PCV, MCV, MCH, and MCHC values were unaffected, however W.B.C count was higher than in control rats. Crispa extract significantly decreased glucose, urea, creatinine, cholesterol, bilirubin, AST, and ALT levels, while increasing triglycerides and total protein levels.

Conclusions: P. crispa extract is high in bioactive components and has significant antioxidant effects, according to this study. The extract was also determined to be safe, with no negative impacts on haematological indicators and positive effects on biochemical parameters.

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